Advances in 4D Bio-Printing Technology for Enhanced Drug Delivery Systems
DOI:
https://doi.org/10.57159/jcmm.3.4.24142Keywords:
4D Bio-Printing, Drug Delivery, Personalized Medicine, Stimuli-Responsive Materials, Biocompatible Polymers, Controlled ReleaseAbstract
This mini-review covers the premise of how 4D bio-printing constitutes the next step out of the realm of 3D bio-printing by establishing time as a functional dimension. While structures derived from 3D bio-printing are static, 4D-bio-printed structures have time to change shape by responding to a certain external stimulus such as temperature or light. This review of materials and processes for use in 4D bio-printing looks at how this will improve drug delivery systems. With this technology, the systems can now be designed so that they not only administer drugs in a controlled manner but also adjust to meet the needs of the concerned patient. Such adaptability opens avenues for further personalized medicine, whereby treatments are more tailored to the patient's specific needs. Development of complex drug delivery systems - Bio-printing in 4D brings hope to deliver formulations that had been difficult to realize earlier. These include multi-chamber devices or bio-erodible materials that degrade the safety feature once the therapeutic payload has been delivered to the body. Thus, 4D bio-printing offers a possibility for more effective treatments and better health results in defeating some of the potential shortcomings in the traditional drug delivery approaches. The potential this technology brings in terms of versatility towards personalized medicine portends a considerable influence over the future of healthcare through adaptive, patient-specific solutions.
References
B. Gao, Q. Yang, X. Zhao, G. Jin, Y. Ma, and F. Xu, “4D bioprinting for biomedical applications,” Trends in Biotechnology, vol. 34, no. 9, pp. 746–756, 2016.
R. Noroozi, Z. U. Arif, H. Taghvaei, M. Y. Khalid, H. Sahbafar, A. Hadi, A. Sadeghianmaryan, and X. Chen, “3D and 4D bioprinting technologies: A game changer for the biomedical sector?” Annals of Biomedical Engineering, vol. 51, no. 8, pp. 1683–1712, 2023.
K. R. Ryan, M. P. Down, and C. E. Banks, “Future of additive manufacturing: Overview of 4D and 3D printed smart and advanced materials and their applications,” Chemical Engineering Journal, vol. 403, p. 126162, 2021.
Y. S. Lui, W. T. Sow, L. P. Tan, Y. Wu, Y. Lai, and H. Li, “4D printing and stimuli-responsive materials in biomedical aspects,” Acta Biomaterialia, vol. 92, pp. 19–36, 2019.
D. G. Tamay, T. Dursun Usal, A. S. Alagoz, D. Yucel, N. Hasirci, and V. Hasirci, “3D and 4D printing of polymers for tissue engineering applications,” Frontiers in Bioengineering and Biotechnology, vol. 7, p. 164, 2019.
K. Osouli-Bostanabad, T. Masalehdan, R. M. Kapsa, A. Quigley, A. Lalatsa, K. F. Bruggeman, S. J. Franks, R. J. Williams, and D. R. Nisbet, “Traction of 3D and 4D printing in the healthcare industry: From drug delivery and analysis to regenerative medicine,” ACS Biomaterials Science & Engineering, vol. 8, no. 7, pp. 2764–2797, 2022.
I. Sahafnejad-Mohammadi, M. Karamimoghadam, A. Zolfagharian, M. Akrami, and M. Bodaghi, “4D printing technology in medical engineering: A narrative review,” Journal of the Brazilian Society of Mechanical Sciences and Engineering, vol. 44, no. 6, p. 233, 2022.
A. Farazin, C. Zhang, A. Gheisizadeh, and A. Shahbazi, “3D bio-printing for use as bone replacement tissues: A review of biomedical application,” Biomedical Engineering Advances, vol. 5, p. 100075, 2023.
W. Zhou, Z. Qiao, E. Nazarzadeh Zare, J. Huang, X. Zheng, X. Sun, M. Shao, H. Wang, X. Wang, D. Chen, et al., “4D-printed dynamic materials in biomedical applications: Chemistry, challenges, and their future perspectives in the clinical sector,” Journal of Medicinal Chemistry, vol. 63, no. 15, pp. 8003–8024, 2020.
X. Wang, Y. He, Y. Liu, and J. Leng, “Advances in shape memory polymers: Remote actuation, multi-stimuli control, 4D printing and prospective applications,” Materials Science and Engineering: R: Reports, vol. 151, p. 100702, 2022.
M. Shahbazi, H. Jäger, R. Ettelaie, A. Mohammadi, and P. A. Kashi, “Multimaterial 3D printing of self-assembling smart thermo-responsive polymers into 4D printed objects: A review,” Additive Manufacturing, vol. 71, p. 103598, 2023.
M. Askari, M. A. Naniz, M. Kouhi, A. Saberi, A. Zolfagharian, and M. Bodaghi, “Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: A comprehensive review with focus on advanced fabrication techniques,” Biomaterials Science, vol. 9, no. 3, pp. 535–573, 2021.
P. Abdollahiyan, B. Baradaran, M. de la Guardia, F. Oroojalian, and A. Mokhtarzadeh, “Cutting-edge progress and challenges in stimuli-responsive hydrogel microenvironment for success in tissue engineering today,” Journal of Controlled Release, vol. 328, pp. 514–531, 2020.
F. Momeni, S. M. Mehdi Hassani, X. Liu, and J. Ni, “A review of 4D printing,” Materials & Design, vol. 122, pp. 42–79, 2017.
F. Momeni and J. Ni, “Laws of 4D printing,” Engineering, vol. 6, no. 9, pp. 1035–1055, 2020.
B. Subeshan, Y. Baddam, and E. Asmatulu, “Current progress of 4D-printing technology,” Progress in Additive Manufacturing, vol. 6, pp. 495–516, 2021.
Y.-C. Li, Y. S. Zhang, A. Akpek, S. R. Shin, and A. Khademhosseini, “4D bioprinting: The next-generation technology for biofabrication enabled by stimuli-responsive materials,” Biofabrication, vol. 9, no. 1, p. 012001, 2016.
M. A. Naniz, M. Askari, A. Zolfagharian, M. A. Naniz, and M. Bodaghi, “4D printing: A cutting-edge platform for biomedical applications,” Biomedical Materials, vol. 17, no. 6, p. 062001, 2022.
U. K. Vates, S. Mishra, N. J. Kanu, et al., “Biomimetic 4D printed materials: A state-of-the-art review on concepts, opportunities, and challenges,” Materials Today: Proceedings, vol. 47, pp. 3313–3319, 2021.
S. Miao, H. Cui, M. Nowicki, L. Xia, X. Zhou, S.-J. Lee, W. Zhu, K. Sarkar, Z. Zhang, and L. G. Zhang, “Stereolithographic 4D bioprinting of multiresponsive architectures for neural engineering,” Advanced Biosystems, vol. 2, no. 9, p. 1800101, 2018.
Q. Yang, B. Gao, and F. Xu, “Recent advances in 4D bioprinting,” Biotechnology Journal, vol. 15, no. 1, p. 1900086, 2020.
A. Bajpai, A. Baigent, S. Raghav, C. Ó. Brádaigh, V. Koutsos, and N. Radacsi, “4D printing: Materials, technologies, and future applications in the biomedical field,” Sustainability, vol. 12, no. 24, p. 10628, 2020.
Z. U. Arif, M. Y. Khalid, A. Zolfagharian, and M. Bodaghi, “4D bioprinting of smart polymers for biomedical applications: Recent progress, challenges, and future perspectives,” Reactive and Functional Polymers, vol. 179, p. 105374, 2022.
M. Ramezani and Z. Mohd Ripin, “4D printing in biomedical engineering: Advancements, challenges, and future directions,” Journal of Functional Biomaterials, vol. 14, no. 7, p. 347, 2023.
P. Pourmasoumi, A. Moghaddam, S. Nemati Mahand, F. Heidari, Z. Salehi Moghaddam, M. Arjmand, I. Kühnert, B. Kruppke, H.-P. Wiesmann, and H. A. Khonakdar, “A review on the recent progress, opportunities, and challenges of 4D printing and bioprinting in regenerative medicine,” Journal of Biomaterials Science, Polymer Edition, vol. 34, no. 1, pp. 108–146, 2023.
D. Schmaljohann, “Thermo- and pH-responsive polymers in drug delivery,” Advanced Drug Delivery Reviews, vol. 58, no. 15, pp. 1655–1670, 2006.
J. Leng, X. Lan, Y. Liu, and S. Du, “Shape-memory polymers and their composites: Stimulus methods and applications,” Progress in Materials Science, vol. 56, no. 7, pp. 1077–1135, 2011.
P. M. Mendes, “Stimuli-responsive surfaces for bio-applications,” Chemical Society Reviews, vol. 37, no. 11, pp. 2512–2529, 2008.
J. A. Stella, A. D’Amore, W. R. Wagner, and M. S. Sacks, “On the biomechanical function of scaffolds for engineering load-bearing soft tissues,” Acta Biomaterialia, vol. 6, no. 7, pp. 2365–2381, 2010.
A. Tabrizikahou, M. Kuczma, P. Nowotarski, M. Kwiatek, and A. Javanmardi, “Sustainability of civil structures through the application of smart materials: A review,” Materials, vol. 14, no. 17, p. 4824, 2021.
N. Ashammakhi, S. Ahadian, F. Zengjie, K. Suthiwanich, F. Lorestani, G. Orive, S. Ostrovidov, and A. Khademhosseini, “Advances and future perspectives in 4D bioprinting,” Biotechnology Journal, vol. 13, no. 12, p. 1800148, 2018.
I. Lukin, S. Musquiz, I. Erezuma, T. H. Al-Tel, N. Golafshan, A. Dolatshahi-Pirouz, and G. Orive, “Can 4D bioprinting revolutionize drug development?” Expert Opinion on Drug Discovery, vol. 14, no. 10, pp. 953–956, 2019.
Downloads
Published
How to Cite
License
Copyright (c) 2024 Journal of Computers, Mechanical and Management
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The Journal of Computers, Mechanical and Management applies the CC Attribution- Non-Commercial 4.0 International License to its published articles. While retaining copyright ownership of the content, the journal permits activities such as downloading, reusing, reprinting, modifying, distributing, and copying of the articles, as long as the original authors and source are appropriately cited. Proper attribution is ensured by citing the original publication.
Accepted 2024-10-13
Published 2024-10-31